1 million due to complications of cirrhosis
1 million due to viral hepatitis
and hepatocellular carcinoma
are diagnosed with alcohol-use disorders
and are at risk
of alcohol-associated liver disease
most common cause of death
Cirrhosis is within the top 20 causes of disability-adjusted life years and years
of life lost, accounting for 1.6% and 2.1% of the worldwide burden
adults are obese or overweight
and over 400 million have diabetes, both of which are risk factors for non-alcoholic fatty liver disease and hepatocellular carcinoma
NAFLD/NASH is a devastating condition
NASH represents the third wave in metabolic diseases, after the rise of obesity and T2D.
NASH market in U.S, Germany, France, Italy, Spain, U.K, Japan is expected to grow
from $138 million in 2016 to $18.3 billion in 2026.
. Brunt EM, Wong VW, Nobili V, et al. Nat Rev Dis Primers. 2015;1:15080
. Chalasani N, Younossi Z, Lavine JE, et al. Hepatology. 2012;55(6):2005–2023.
. Spengler EK, Loomba R. Mayo Clinic Proceedings. 2015;90(9):1233–1246.
NAFLD (non-alcoholic fatty liver disease)
is a condition where excess fat is stored in the liver
25% of all Americans
40% to 80% of people with Type 2 Diabetes 
30% to 90% of people who are obese 
It can lead to NASH (non-alcoholic steatohepatitis) 
with the added presence of hepatitis and liver damage