Liver Diseases, A Global Epidemics

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deaths per year worldwide

1 million due to complications of cirrhosis
1 million due to viral hepatitis and hepatocellular carcinoma
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are diagnosed with alcohol-use disorders

and are at risk of alcohol-associated liver disease
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most common cause of death

Cirrhosis is within the top 20 causes of disability-adjusted life years and years of life lost, accounting for 1.6% and 2.1% of the worldwide burden
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adults are obese or overweight

and over 400 million have diabetes, both of which are risk factors for non-alcoholic fatty liver disease and hepatocellular carcinoma




NAFLD/NASH is a devastating condition


NASH represents the third wave in metabolic diseases, after the rise of obesity and T2D.

NASH market in U.S, Germany, France, Italy, Spain, U.K, Japan is expected to grow
from $138 million in 2016 to $18.3 billion in 2026.
References
[1]. Brunt EM, Wong VW, Nobili V, et al. Nat Rev Dis Primers. 2015;1:15080 [2]. Chalasani N, Younossi Z, Lavine JE, et al. Hepatology. 2012;55(6):2005–2023. [3]. Spengler EK, Loomba R. Mayo Clinic Proceedings. 2015;90(9):1233–1246.



NAFLD (non-alcoholic fatty liver disease)

is a condition where excess fat is stored in the liver


It can lead to NASH (non-alcoholic steatohepatitis) [2]

with the added presence of hepatitis and liver damage